The Sakamaki Family is the first family of vampires presented in this series. They are pureblood vampires.

The family consists of Karlheinz, the King of the Vampires, his three wives: Cordelia, Beatrix and Christa, and his six sons: Shu, Reiji, Ayato, Kanato, Laito and Subaru. The brothers are not very close yet despite their differences live together in their own mansion.

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